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This upregulation correlated with reductions in adipose tissue mass
24 Novo Nordisk overcame these barriers by formulating with sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC), which acts both as a buffering agent, protecting the peptide from acid degradation, and a permeation enhancer, to increase absorption
Figure 1 shows the milestones of this development
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